Our searches revealed no trials that met the inclusion criteria for the review. All participants tolerated the treatment well, and there were no major complications. The paralysis causes distortion of the face and interferes with normal functions, such as closing the eye and eating.
Randomised controlled trials are needed to establish the value of immunotherapies or other treatments. For this updated review we found a total of 12 studies with participants, most with high risk of bias.
Idiopathic facial palsy and physical therapy: The trial involved 79 participants and compared hyperbaric oxygen therapy to prednisone, a corticosteroid, which is a proven active treatment.
The quality of evidence from this trial was very low because the assessors of facial function were aware of which treatment each participant had been given, which introduces a high risk of bias. There is insufficient evidence to decide whether electrical stimulation works, to identify risks of these treatments or to assess whether the addition of acupuncture to facial exercises or other physical therapy could produce improvement.
Physical therapies, such as exercise, biofeedback, laser treatment, electrotherapy, massage and thermotherapy, are used to hasten recovery, improve facial function and minimise sequelae. Corticosteroids such as prednisolone reduce inflammation and so should reduce nerve damage.
Standard treatment includes steroids to help settle swelling of the facial nerve, whereas antiviral treatment does not appear to help. The facial palsy gets completely better without treatment in most, but not all, people.
Reducing inflammation of the facial nerve using corticosteroid medicines steroids is thought to limit nerve damage. December 18, Immunotherapy for Guillain-Barre syndrome: The review was generally well conducted and its conclusions seem reliable.
The participants did not know which treatment they were being given. More trials are needed to assess the effects of facial exercises and any risks.
The symptoms probably occur when a nerve in the face is trapped and swollen. November 15, To assess the effects of treatments for fatigue in people with peripheral neuropathy. It is thought to be caused by inflammation of the facial nerve.
IVIG appeared more effective than placebo in relapsing-remitting multiple sclerosis and idiopathic chronic inflammatory demyelinating polyneuropathy. Some surgeons have thought that an operation to free the nerve could improve recovery.
It is difficult to assess the reliability of these conclusions given the diversity of the studies and the lack of a study quality assessment. Cochrane Database of Systematic Reviews: This is an update of a review first published in and last updated in Guillain-Barre Syndrome-Pipeline Insights, â?, report provides comprehensive insights of the ongoing therapeutic research and development across Guillain-Barre Syndrome.
The report provides a complete understanding of the pipeline activities covering. Key diagnostic criteria and Brighton case definitions for Guillain-Barré syndrome. Govoni V, Granieri E () Epidemiology of the Guillain-Barre syndrome.
Curr Opin Neurol – CrossRef PubMed Google Scholar. Incidence of Guillain-Barré syndrome among patients with Campylobacter infection: a general practice research database. The pathogenesis of Guillain-Barré syndrome (GBS) is considered to be, at least in part, mediated by autoantibodies directed against neuronal antigens.
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Guillain-Barré syndrome is thought to be caused by a problem with the immune system, the body's natural defence against illness and infection. Normally the immune system attacks any germs that get into the body.
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